Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net	Kernel	Elements	Min	Max	Average	Standard_Deviation
biological_process	ct	19	0.001	0.32	0.148	0.091
biological_process	el	19	0.52	0.971	0.867	0.104
biological_process	ka	19	0.0	0.332	0.134	0.091
biological_process	rf	19	0.001	0.32	0.148	0.091
cellular_component	ct	19	0.001	0.612	0.195	0.161
cellular_component	el	19	0.006	0.685	0.334	0.243
cellular_component	ka	19	0.0	0.618	0.189	0.162
cellular_component	rf	19	0.001	0.612	0.195	0.161
disease	ct	9	0.03	0.647	0.335	0.236
disease	el	9	0.188	0.988	0.55	0.257
disease	ka	9	0.003	0.601	0.325	0.228
disease	rf	9	0.03	0.646	0.335	0.236
genetic_interaction	ct	17	0.0	0.975	0.544	0.31
genetic_interaction	el	17	0.0	0.976	0.557	0.306
genetic_interaction	ka	17	0.0	1.0	0.882	0.322
genetic_interaction	rf	17	0.0	0.965	0.545	0.307
molecular_function	ct	19	0.003	0.804	0.237	0.226
molecular_function	el	19	0.144	0.876	0.413	0.273
molecular_function	ka	19	0.007	0.807	0.234	0.233
molecular_function	rf	19	0.003	0.804	0.237	0.226
pathway	ct	19	0.001	0.909	0.505	0.312
pathway	el	19	0.001	0.711	0.369	0.263
pathway	ka	19	0.001	1.0	0.843	0.363
pathway	rf	19	0.001	0.704	0.347	0.24
phenotype	ct	9	0.006	0.651	0.438	0.24
phenotype	el	9	0.227	0.769	0.482	0.218
phenotype	ka	9	0.003	0.703	0.472	0.264
phenotype	rf	9	0.006	0.651	0.438	0.24
protein_interaction	ct	19	0.002	0.4	0.16	0.11
protein_interaction	el	19	0.003	0.258	0.091	0.07
protein_interaction	ka	19	0.008	1.0	0.74	0.435
protein_interaction	rf	19	0.002	0.386	0.149	0.104

Table 2. Backup position values for every kernel after integration

Integration	Kernel	Elements	Min	Max	Average	Standard_Deviation
integration_mean_by_presence	ct	19	0.006	0.769	0.301	0.234
integration_mean_by_presence	el	19	0.108	0.744	0.434	0.197
integration_mean_by_presence	ka	19	0.001	0.616	0.294	0.197
integration_mean_by_presence	rf	19	0.0	0.854	0.298	0.265
mean	ct	19	0.0	0.715	0.197	0.21
mean	el	19	0.0	0.564	0.172	0.148
mean	ka	19	0.0	0.311	0.121	0.105
mean	rf	19	0.0	0.381	0.139	0.129

CDF plots of non integrated kernels

CDF plots of integrated kernels