Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 19 0.001 0.32 0.148 0.091
biological_process el 19 0.52 0.971 0.867 0.104
biological_process ka 19 0.0 0.332 0.134 0.091
biological_process rf 19 0.001 0.32 0.148 0.091
cellular_component ct 19 0.001 0.612 0.195 0.161
cellular_component el 19 0.006 0.685 0.334 0.243
cellular_component ka 19 0.0 0.618 0.189 0.162
cellular_component rf 19 0.001 0.612 0.195 0.161
disease ct 9 0.03 0.647 0.335 0.236
disease el 9 0.188 0.988 0.55 0.257
disease ka 9 0.003 0.601 0.325 0.228
disease rf 9 0.03 0.646 0.335 0.236
genetic_interaction ct 17 0.0 0.975 0.544 0.31
genetic_interaction el 17 0.0 0.976 0.557 0.306
genetic_interaction ka 17 0.0 1.0 0.882 0.322
genetic_interaction rf 17 0.0 0.965 0.545 0.307
molecular_function ct 19 0.003 0.804 0.237 0.226
molecular_function el 19 0.144 0.876 0.413 0.273
molecular_function ka 19 0.007 0.807 0.234 0.233
molecular_function rf 19 0.003 0.804 0.237 0.226
pathway ct 19 0.001 0.909 0.505 0.312
pathway el 19 0.001 0.711 0.369 0.263
pathway ka 19 0.001 1.0 0.843 0.363
pathway rf 19 0.001 0.704 0.347 0.24
phenotype ct 9 0.006 0.651 0.438 0.24
phenotype el 9 0.227 0.769 0.482 0.218
phenotype ka 9 0.003 0.703 0.472 0.264
phenotype rf 9 0.006 0.651 0.438 0.24
protein_interaction ct 19 0.002 0.4 0.16 0.11
protein_interaction el 19 0.003 0.258 0.091 0.07
protein_interaction ka 19 0.008 1.0 0.74 0.435
protein_interaction rf 19 0.002 0.386 0.149 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 19 0.006 0.769 0.301 0.234
integration_mean_by_presence el 19 0.108 0.744 0.434 0.197
integration_mean_by_presence ka 19 0.001 0.616 0.294 0.197
integration_mean_by_presence rf 19 0.0 0.854 0.298 0.265
mean ct 19 0.0 0.715 0.197 0.21
mean el 19 0.0 0.564 0.172 0.148
mean ka 19 0.0 0.311 0.121 0.105
mean rf 19 0.0 0.381 0.139 0.129

CDF plots of non integrated kernels

CDF plots of integrated kernels